Hormone Therapy and Insulin Resistance: A Game-Changer for Menopausal Metabolic Health
Anna Harrelson • February 11, 2025
Menopause, Metabolism, and Hormones: How Estrogen Impacts Insulin Resistance and Why It Matters
As a menopause specialist, lifestyle medicine physician, and a perimenopausal woman with a family history of metabolic syndrome, I have a deep, personal and professional investment in the role of metabolic health during menopause. Preventing insulin resistance and diabetes is not just a clinical goal—it’s something I think about daily.
A groundbreaking meta-analysis recently published by The Menopause Society sheds light on an area that has long been debated: the relationship between hormone therapy (HT) and insulin resistance. This research reviewed 17 randomized controlled trials encompassing over 29,000 participants, finding that menopausal hormone therapy—including both estrogen alone and estrogen plus progestogen—can significantly reduce insulin resistance in healthy postmenopausal women.
This study is not just an academic curiosity. It has real, actionable implications for midlife women who are trying to navigate the complex landscape of hormonal changes, weight shifts, and metabolic health challenges. Let’s break down what this means, why it matters, and how we can apply this research to both clinical decision-making and personal wellness.
Understanding Insulin Resistance and Menopause
Insulin resistance is a condition where cells in the body become less responsive to insulin, leading to elevated blood glucose levels, increased fat storage (especially around the midsection), and a greater risk for developing type 2 diabetes. Estrogen plays a key role in regulating glucose metabolism, insulin sensitivity, and fat distribution, which is why the transition into menopause—when estrogen levels drop—often correlates with increased abdominal fat and metabolic dysfunction.
Many women find themselves frustrated, feeling like they’re doing everything right from a lifestyle perspective, only to see weight accumulate in their midsection. What used to work no longer does, and this can be incredibly disheartening. While medications exist that may seem like a quick fix, understanding the role of hormones and lifestyle remains critical in long-term metabolic health.
What the Study Found
This meta-analysis provides strong evidence that hormone therapy may not only alleviate traditional menopause symptoms but could also serve as a protective factor against insulin resistance. Here’s what stood out:
- Reduction in Insulin Resistance: HT was associated with a statistically significant reduction in insulin resistance markers across all included studies.
- Estrogen Alone vs. Estrogen + Progestogen: While both forms of HT improved insulin sensitivity, estrogen-only therapy showed slightly more pronounced benefits.
- Route of Administration Matters: Both oral and transdermal (patches, gels) routes showed efficacy, but different formulations may impact metabolic outcomes uniquely.
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No Increased Diabetes Risk: Contrary to outdated concerns, this research did not find an increased risk of diabetes with hormone therapy use.
The Bigger Picture: Cortisol, Stress, and Metabolic Dysfunction
While estrogen clearly plays a key role in metabolic regulation, it’s not the only factor at play. Stress—and its impact on cortisol—also significantly influences insulin sensitivity. Chronic stress, disrupted circadian rhythms, poor sleep, and lifestyle factors all contribute to increased insulin resistance, making menopause an even more vulnerable period for metabolic dysfunction.
Additionally, many women unknowingly exacerbate metabolic issues by under-eating and over-exercising. Chronic caloric restriction and excessive cardio without adequate strength training can drive up cortisol levels, leading to worsened insulin sensitivity, increased fat storage, and hormonal imbalances.
One of the most powerful tools for metabolic health is muscle. Muscle acts as a “sink” for glucose, helping regulate blood sugar and improve insulin sensitivity. The more muscle mass we maintain, the better our glucose control. For those struggling with insulin resistance or unexplained weight gain, a two-week trial using a continuous glucose monitor (CGM) can provide valuable insights into how their body processes glucose, helping them make more informed dietary and lifestyle decisions. Keeping blood sugar balanced and avoiding spikes is key to reducing insulin resistance and maintaining optimal metabolic health.
What Does This Mean for You?
If you are a perimenopausal or postmenopausal woman concerned about metabolic health, here are key takeaways:
1. Hormone Therapy Isn’t Just for Hot Flashes – If you’re struggling with weight gain, insulin resistance, or metabolic shifts, HT may be a powerful tool to help stabilize your metabolism and improve insulin sensitivity.
2. Individualized Care is Essential – This study reinforces the importance of personalized medicine. The “best” HT formulation varies by individual risk factors, medical history, and metabolic profile.
3. Lifestyle Still Matters– HT can be part of the solution, but optimizing metabolic health also requires dietary adjustments, regular strength training, sleep hygiene, and stress management.
4. Not Everyone Can or Should Take HT– While HT has clear benefits, not all women are candidates. That doesn’t mean they are destined for insulin resistance or diabetes. Genetics, lifestyle, and overall metabolic health play major roles, and there are still many ways to reduce risk without hormone therapy.
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Advocacy is Key – Many clinicians still view HT through the outdated lens of the Women’s Health Initiative (WHI) study from the early 2000s. You deserve care informed by current science. If your doctor dismisses HT outright, it may be time for a second opinion.
Final Thoughts: Staying Ahead of the Research
This research reinforces what I—and many other menopause specialists—have suspected for years: the impact of estrogen on metabolic health extends far beyond its traditional role in symptom management. For those of us who are determined to prevent insulin resistance, diabetes, and metabolic disease in midlife and beyond, these findings should be front and center in our healthcare discussions.
As a menopause physician who tries to stay up to date with the latest research, I am here to provide informed, evidence-based guidance. If you’re navigating perimenopause or menopause and want to take a proactive approach to your health, I’d love to help you explore your options, including whether hormone therapy could be beneficial for you.
Because menopause isn’t just about surviving the transition—it’s about thriving in midlife and beyond.
WonderCreek Health Blog
You’re not crazy. You’re not lazy. And no, you’re not just "getting older." If you’re dragging through your days, feeling foggy, heavy, or worn out—but your labs are "normal"—you’re not alone. One of the most overlooked causes I find in my practice is suboptimal ferritin levels. Let’s break it down—with science, a little wit, and a whole lot of hope. Your Body: A High-Performance Machine Imagine your body like a beautifully engineered, high-performance car. Hormones are your spark plugs. Micronutrients are your engine oil. Proteins are your gears and pulleys. Without the right balance of all these building blocks, the engine sputters. It doesn’t matter how good the outside looks—if you're low on fuel or missing key fluids, you’re not getting out of the driveway. And iron —stored as ferritin—is a huge part of that fuel system. What Is Ferritin, and Why Should You Care? Ferritin is your body's iron storage protein. It’s like your gas tank. Not your current speed, not your miles per gallon—your actual reserve of fuel. Iron is essential for carrying oxygen to every cell in your body. It's crucial for energy production (ATP) in your mitochondria. It supports your thyroid, neurotransmitter function, hair growth, immune system, and even mood. If you’re low on ferritin, you might still show " normal " hemoglobin or hematocrit—so traditional screening won’t catch it until you’re running on fumes. Symptoms of suboptimal ferritin can include: Fatigue and poor exercise tolerance Brain fog or poor concentration Mood swings or low mood Headaches Hair shedding Shortness of breath with minimal exertion Restless legs or poor sleep Sound familiar? But My Labs Say I'm Normal... Here's the kicker: most lab ranges are designed to flag anemia — not optimal function. You could have a ferritin of 12 and be told " everything looks fine " — but feel absolutely awful. For most women, especially those who are still menstruating or recently stopped, ferritin levels under 40–60 ng/mL can cause symptoms . Many functional and integrative medicine specialists aim for 70–100+ ng/mL to support optimal energy, cognition, and hair health. Low-normal is not optimal. When your engine light is blinking, topping off the tank halfway doesn’t cut it. Why You Might Be Low Menstruation: Every period can deplete iron stores, especially if cycles were heavy. Pregnancy and postpartum: Even years later, many women never rebuild their iron stores. Gut health issues: Poor absorption due to low stomach acid, celiac disease, or IBS. Dietary patterns: Plant-based diets can be low in easily absorbed heme iron. Chronic inflammation: Inflammatory signals can "hide" your iron from circulation. Food First, But Realistic Yes, food matters. Red meat, poultry, seafood, lentils, spinach, and pumpkin seeds all contribute iron. But rebuilding storage? That’s a bigger lift. Think of dietary iron like filling up your gas tank 10–15% at a time. Helpful, but slow if you're starting on empty. Sometimes you need a boost. That’s where targeted supplementation can help—whether it’s gentle oral iron (like iron bisglycinate) or occasional intravenous iron if needed. And by the way, ever wonder why "senior" vitamins have no iron? Because postmenopausal women typically don’t lose blood monthly. We don’t want too much iron. But we also can’t function with too little. Balance is everything. Final Thoughts If you’re feeling run down, foggy, achy, or unlike yourself—it’s not "all in your head." Your body is whispering (or screaming) for better support. And sometimes the missing piece isn’t fancy. It’s basic, foundational, and fixable. Ferritin matters. Iron matters. You matter. At Wondercreek Health, I believe in digging deeper, connecting the dots, and helping you rebuild the strong, steady foundation your body deserves. Because you weren’t designed to run on empty. Iron-Rich Foods to Boost Your Levels Beef, lamb, liver (heme iron is best absorbed) Dark poultry (chicken thighs, turkey) Shellfish (clams, oysters, mussels) Lentils and chickpeas Spinach and swiss chard Pumpkin seeds and cashews Fortified cereals and oatmeal Tofu and tempeh Tip: Pair iron-rich foods with vitamin C (like bell peppers, oranges, or strawberries) to boost absorption! Ferritin Target Chart Ferritin Level What It Means <15 ng/mL Severe deficiency 15–40 ng/mL Low stores (symptoms likely) 40–60 ng/mL Borderline (may still have symptoms) 70–100+ ng/mL Optimal for energy, cognition, hair health Individual needs vary—always interpret ferritin in the context of your full health picture! When to Suspect Low Iron Feeling tired despite good sleep Exercise feels harder than it used to Brain fog or poor memory Unexplained hair thinning Pale skin or brittle nails Frequent headaches Restless legs or poor sleep Shortness of breath climbing stairs If you’re nodding along to several of these, it’s worth a closer look at your ferritin levels.
Let’s start with this: there is nothing shameful or trivial about wanting a healthy sex life. If you're in your 30s, 40s, 50s, or beyond and wondering where your libido went, why sex feels different (or uncomfortable), or why no one ever warned you about vaginal dryness, you’re not alone. And you’re not imagining it. At Wondercreek Health, I talk to people every week who feel confused, dismissed, or ashamed about the sexual changes happening in their bodies. Many are thriving in every other area of life—careers, caregiving, health—but when it comes to intimacy, they feel stuck or unseen. So let’s say this together: sexual health is part of whole-person health. And pleasure is not optional . It’s a reflection of nervous system safety, hormonal balance, connection, and self-awareness. It belongs to you. What Happens to Sexual Health in Midlife and Beyond? Hormonal shifts during perimenopause and menopause can affect every part of your sexual experience. But so can chronic stress, birth control, antidepressants, trauma, and the weight of daily responsibilities. This is never just one thing. Common symptoms include: Vaginal dryness, burning, or itching (genitourinary syndrome of menopause, or GSM) Pain with sex (dyspareunia) Loss of libido or arousal Less intense or harder-to-reach orgasms Urinary urgency or UTIs Pelvic floor tension or dysfunction These changes aren’t "just in your head" and they’re not a moral failure. They reflect real shifts in tissue, blood flow, hormones, and brain chemistry. Sex Isn’t Just for Someone Else’s Benefit Let’s say the quiet part out loud: many of us were raised to believe that sex was about someone else's pleasure. That we should be desirable, responsive, available—regardless of how we felt. That conditioning runs deep. But sex isn’t about performance. It’s about connection, intimacy, and pleasure—for you. Pleasure is your birthright. Intimacy can be tender, playful, spiritual, or wild— but it should never feel like pressure. Your desire may look different than someone else's, and that’s okay. This is true whether your partner is male, female, nonbinary, or you're navigating intimacy solo. There is no one-size-fits-all experience. Why Your Desire Might Feel "Off" Sexual changes can happen at any age. Oral contraceptives (OCPs) can suppress libido by lowering free testosterone. SSRIs and other antidepressants are well known to impact arousal and orgasm. Perimenopause often starts in the mid-30s, long before you notice hot flashes. Chronic stress and the mental load of caregiving, multitasking, and decision fatigue can leave no room for desire. Because here’s the reality: desire doesn’t live in your genitals. It starts in your brain . And when your brain is overloaded with to-dos, responsibilities, or unspoken resentment, it’s nearly impossible to shift into a space of curiosity, connection, and arousal. Unwinding the mind can be hard. For some of us, it means learning to use tools like mindfulness, breathwork, somatic practices, therapy, or just having space and time away from the demands of the world. Creating room for desire isn’t selfish. It’s a form of self-trust and reclamation. The Good News: This Is Treatable Sexual health doesn’t have to decline just because estrogen does. There are safe, effective, empowering ways to reconnect with your body and reclaim your pleasure. 1. Local vaginal estrogen (or DHEA or testosterone): Restores tissue health, lubrication, and blood flow Improves comfort, arousal, and pelvic health Safe for most people, even those with a history of breast cancer (with appropriate guidance) 2. Systemic hormone therapy: Can improve libido, mood, sleep, and confidence Testosterone therapy (when indicated) can support arousal and orgasm 3. Pelvic floor physical therapy: Addresses pain, tension, and coordination issues Supports better sensation and comfort 4. Nervous system regulation: Practices like breathwork, somatic therapy, or trauma-informed care help shift from "fight or flight" into connection When the nervous system feels safe, desire can return 5. Sex therapy or coaching: Helps explore personal blocks, relationship dynamics, and pleasure mapping Let’s Talk About Desire You might notice you don’t feel spontaneous desire anymore— but that doesn’t mean you’re broken . For many people, responsive desire (desire that follows arousal) becomes the norm in midlife. And it’s perfectly valid. Touch, connection, and intimacy may need more warming up. But your ability to experience pleasure is still intact—and it can grow deeper, richer, and more grounded as you reconnect with your body on your own terms. Final Thoughts You don’t need to be fixed. You deserve to be heard. You deserve to feel good in your body. Sexual health is not about keeping up with anyone else’s timeline or expectations. It’s about reclaiming what intimacy and connection mean to you in this season of life. At Wondercreek Health, I’m here to help you connect the dots, reduce shame, and support you with science-backed, judgment-free options that honor your experience. Because this is not the end of your sexual story. It might just be the beginning of the most powerful chapter yet.